The Meatpacking District has become so trendy it can make a tourist puke. But there is one well-known off the beaten path gem; Pastis.
After my favorite restaurant, Bolo (damn you Bobby Flay!!!), closed about two years ago we've been spending more meals at Pastis. It is always crowded and expect to wait at least 45 minutes for a table for two during the dinner rush which lasts from ~8:00PM to 11:00PM. They switch to a supper menu at 1:00AM which is a scaled back version of the dinner menu.
Service can be hit or miss but I've never had a bad meal at Pastis. Even dessert at this place is amazing!